This is another pathway the body uses when under chronic stress.
The Thyroid function is to boost metabolism and raise body temperature.
Thyroid Hormones (T3 & T4), increase metabolic rate, the rate of oxygen consumption under standard conditions (awake, at rest, and fasting), by stimulating the use of cellular oxygen to produce ATP (the energy currency of the body). When metabolic rate increases, the cellular metabolism of (macronutrients) Carbohydrates, Lipids and of Proteins increases, so that they can be used as fuel; reducing blood cholesterol level). As body cells produce and use more ATP, more heat is given off, and body temperature rises. In this way, thyroid hormones are therefore vital in maintaining normal body temperature.
Any dysfunction in the production of the hormones, transportation in the blood (requires carrier protein), or to cell receptors sites, can all affect the body’s response to Thyroid Hormones.
Reverse T3 (rT3) is primarily produced from the breakdown of T4 in the peripheral tissues. Physical, mental and environmental stresses can inhibit the enzyme in charge of making T3 from T4, causing less T4 to be converted to T3, thus decreasing the amount of active thyroid hormone available to the cells. More T4 is then shunted towards rT3 causing an elevation in rT3.
When a person produces excessive levels of rT3 they will usually present with hypothyroid symptoms, including cognitive impairment (poor memory/concentration), complete lack of energy/dizziness, low mood, anxiety and depression, in turn, this pushes the brain to send repetitive messages to the thyroid to produce more and more hormones… Until, finally disease (e.g. Hypothyroidism) occurs; the Thyroid completely exhausted.
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